Breast cancer is one of the most common malignancy in women worldwide. Worldwide, there are approximately 2.1 million diagnosed breast cancer cases in 2018. Breast cancer treatments have dramatically increased over the past decade. The surgical removal of whole breast is known as mastectomy and for this reason, women undergo breast reconstruction. Breast reconstruction is a careful procedure to restore breast size and shape during a mastectomy or lumpectomy. There are many different options for the procedure of breast reconstruction. Immediate reconstruction is done at the same time of mastectomy whereas delayed reconstruction is done months or years after the mastectomy. The risk of surgical complications is less in delayed reconstruction as compared to the immediate reconstruction. To reduce the risk of recurrence of breast cancer, many women are treated with radiation therapy after mastectomy. In this chapter of breast cancer reconstruction, we outline the timings and methods of breast reconstruction, factors influencing the breast reconstruction, current trends and role of radiotherapy.